Study: Cannabinoids may Prevent Chemotherapy-Induced Diarrhea, which can be Fatal

Chemotherapy-Induced DiarrheaCannabinoids may prevent chemotherapy-induced diarrhea, which in some cases can be fatal, according to a new study published in the journal Transnational Psychiatry.

The study’s abstract begins by pointing out that; “The antineoplastic drug 5-fluoruracil (5-FU) is a pirimidine analog, which frequently induces potentially fatal diarrhea and mucositis. Cannabinoids reduce gastrointestinal motility and secretion and might prevent 5-FU-induced gut adverse effects. Here, we asked whether cannabinoids may prevent diarrhea and mucositis induced by 5-FU in the rat.”

Using rats and a cannabinoid receptor agonist meant to mimic the effects of cannabinoids, researchers found that it “tended to reduce the severity of 5-FU-induced diarrhea and increased permanence of barium from day 1 to the beginning of day 4 in 5-FU-treated animals. 5-FU-induced mucositis was severe and not counteracted by [the cannabinoid receptor agonist].”

Researchers conclude by stating that “5-FU-induced diarrhea, but not mucositis, was partly prevented by [the cannabinoid receptor agonist] at a low dose. Cannabinoids might be useful to prevent chemotherapy-induced diarrhea.”

The full study, conducted by researchers at the Sapienza University of Rome and the University “Roma Tre”, can be found by clicking here.

About Anthony Martinelli

Anthony, co-founder and Editor-in-Chief of TheJointBlog, has worked closely with numerous elected officials who support cannabis law reform, including as the former Campaign Manager for Washington State Representative Dave Upthegrove. He has also been published by multiple media outlets, including the Seattle Times. He can be reached at

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